What is SARM (selective androgen receptor modulators)?
Clinical studies ostarine suppressive have shown no suppression of testosterone in the remainder of the testicles. The antiquities have been developed as a safe alternative to steroids for muscle growth
Selective androgen receptor modulators (abbreviated as -SARM) are newly discovered molecules that bind to specific androgen receptors in the human body (eg, bone and muscle tissue). They have effects similar to anabolic steroids, but are very selective in their action and thus do not give different undesirable side effects, as happens in the case of steroids.
Unlike steroids, which are usually injected, SARM is taken orally. Their action is directed selectively to androgen receptors in different tissues. Only those cells that are the object of therapy will react, while the rest of the body will not be affected. There are many types of SARM (arylpropionamides, quinolinones, bicyclic hydantoins, quinolines), although the most perfect SARMs today are aryl propionamides such as ostarine and annarin (S-4 and S-23).
None of the SARMs currently developed has an ideal anabolic effect limited only to muscles and bone tissue, but many of them are very close to it. If the effect of the anabolic effect of testosterone androgen is 1: 1, then the effect of some SARM is 10: 1. For example, if the goal was to promote bone growth in elderly men with osteoporosis and at the same time not stimulate the testes and the prostate, then SARM ostarine testosterone aimed at bone and muscle tissue, and with minimal effect on the reproductive organs, will be much more suitable than testosterone treatment. Likewise, if the goal was to stimulate libido and other sexual functions in women, and at the same time not to cause negative side effects, such as the development of masculine traits (virilization), then SARM will be as effective as possible.
SARM have been developed since the early 2000s. The first test in 2003 demonstrated the effectiveness of these substances. Currently, there are a number of drugs of this orientation, which are of great interest for bodybuilders.
An important advantage of selective androgen receptor modifiers is that they are taken orally, which helps to avoid liver damage, while most anabolic steroids need to be injected, which eventually has a negative effect on the liver. In this respect, SARM is safer.
What is Ostarine Suppressive (MK-2866, S-22)?
Full chemical name: (2S) -3- (4-cyanophenoxy) -N- [4-cyano-3- (trifluoromethyl) phenyl] -2-hydroxy-2-methylpropanamide.
Ostarine Suppressive is a non-steroidal selective androgen receptor modulator that binds to a specific androgen receptor. It is also known under the names: Enobosarm ostarine testosterone, MK-2866, GTx-024 and S-22. The drug was developed by the pharmaceutical company GTX, inc as a treatment for diseases such as muscle wasting, osteoporosis and andropause.
As follows from the article published on the site of the US National Center for Biotechnology Information, Enobosarm demonstrated good results in clinical trials of phases I and II, showing an increase in the total mass of “dry” muscles, increasing endurance and reducing the overall percentage of fat tissue. Ostarine acts as a powerful anabolic agent with minimal side effects on other organs (hair follicles, prostate), which are usually affected by steroids.
At the moment, GTx has conducted 8 clinical trials, in which 600 volunteers participated, including three studies aimed at identifying efficacy. During the 4-month clinical trial, 159 patients were registered, who confirmed their goal: total weight gain and activation of muscle functions.
Possible use of Ostarine Suppressive
S22 affects both muscular and bone tissue, it was developed to treat osteoporosis, andropause and reversal of muscular sarcopenia in the elderly and cachexia in cancer patients.
SARMs and Ostarine Suppressive in bodybuilding and sport
Because SARM was widely used by athletes to gain strength, strength and physical fitness, they were banned by the World Anti-Doping Agency (WADA) in January 2008. Since then, several athletes have been caught and disqualified ostarine testosterone, because their tests for Ostarine Suppressive were positive.
Professional bodybuilders mainly use S-22 between cycles of steroids to maintain progress made with other substances. For beginners, the MK-2866 is a good start, since it does not require injections and does not damage the liver, there are no side effects that are usually associated with the use of steroids. Ostarine Suppressive is used to both increase muscle mass, and to reduce fat deposits or recompile (simultaneously building muscle and burning fat). GTx-024 is still an experimental drug and should be considered as such.